MC1 Receptor antibody

Catalog No. ABIN317707

Product Details anti-MC1 Receptor Antibody

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects endogenous levels of MC1-R protein (region surrounding Val312).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/1000approx. 1/10000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1-R (MC1R Products)

Synonyms: CMM5 antibody, MSH-R antibody, SHEP2 antibody, Mshra antibody, Tob antibody, e antibody, MC1-R antibody, MSHR antibody, mc1r antibody, MC1R antibody, TUBB3 antibody, melanocortin 1 receptor antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody, MC1R antibody, Mc1r antibody, mc1r antibody, mc1r_par1 antibody

Background: The melanocortin family comprises the alpha-, beta- and gamma-melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.Synonyms: MC1R, MSH-R, MSHR, Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor

Molecular Weight: approx. 35 kDa

Gene ID: 4157

NCBI Accession: NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour