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MAPT antibody (Microtubule-Associated Protein tau) (pSer356)

Details for Product anti-MAPT Antibody No. ABIN319219, Supplier: Log in to see
Antigen
  • tau
  • xtp
  • MAPT
  • AI426939
  • AI551861
  • AW457082
  • CK1epsilon
  • CKIe
  • KC1epsilon
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • AI413597
  • AW045860
  • Mtapt
  • Tau
  • PHF-tau
  • RNPTAU
  • pTau
  • microtubule-associated protein tau
  • Microtubule-associated protein tau
  • casein kinase 1, epsilon
  • mapt
  • MAPT
  • AaeL_AAEL015538
  • AaeL_AAEL012206
  • CpipJ_CPIJ013260
  • tau
  • Csnk1e
  • Mapt
Epitope
pSer356
60
42
37
36
35
35
34
32
28
27
26
26
23
17
17
17
16
16
15
12
11
11
10
9
9
9
8
8
8
8
7
7
7
7
6
6
6
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
981
626
602
131
46
44
42
33
24
16
11
10
4
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
Host
Rabbit
880
139
11
7
Clonality
Polyclonal
Conjugate
This MAPT antibody is un-conjugated
25
10
10
7
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
915
332
301
139
88
55
54
52
17
14
13
12
12
12
9
7
4
1
Options
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Immunogen Synthetic phosphopeptide derived from human Tau around the phosphorylation site of serine 356 (I-G-SP-L-D).
Purification Affinity chromatography
Alternative Name MAPT / tau (MAPT Antibody Abstract)
Background Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
Gene ID 9606
UniProt P10636
Research Area Cytoskeleton
Pathways MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size
Application Notes Western blot (1/500-1/1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-MAPT antibody (Microtubule-Associated Protein tau) (pSer356) (ABIN319219) anti-Microtubule-Associated Protein tau (MAPT) (pSer356) antibody
 image for anti-MAPT antibody (Microtubule-Associated Protein tau) (pSer356) (ABIN319219) anti-Microtubule-Associated Protein tau (MAPT) (pSer356) antibody (Image 2)
Background publications Puig, Rey, Ferrer: "Individual and regional variations of phospho-tau species in progressive supranuclear palsy." in: Acta neuropathologica, Vol. 110, Issue 3, pp. 261-8, 2005 (PubMed).

DeGiorgis, Jaffe, Moreira, Carlotti, Leite, Pant, Dosemeci: "Phosphoproteomic analysis of synaptosomes from human cerebral cortex." in: Journal of proteome research, Vol. 4, Issue 2, pp. 306-15, 2005 (PubMed).

Alonso, Mederlyova, Novak, Grundke-Iqbal, Iqbal: "Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34873-81, 2004 (PubMed).

Kyriakis, Banerjee, Nikolakaki, Dai, Rubie, Ahmad, Avruch, Woodgett: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).