KIT antibody (Mast/stem Cell Growth Factor Receptor) (pTyr936)

Details for Product anti-KIT Antibody No. ABIN319288, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
  • kit oncogene
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Kit
  • KIT
Alternatives
anti-Human KIT antibody for Cytometry by Time of Flight
Epitope
pTyr936
56
43
40
32
27
25
25
17
16
15
15
15
15
15
14
11
10
10
10
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7
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5
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3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
Reactivity
Human
944
491
158
47
42
32
28
19
15
6
6
5
4
3
2
1
1
Host
Rabbit
688
284
242
4
2
1
Clonality
Polyclonal
Conjugate
This KIT antibody is un-conjugated
106
91
91
62
50
39
22
18
14
10
10
10
10
9
9
8
8
8
8
8
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7
5
5
5
5
5
5
5
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4
4
4
3
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
435
410
405
215
179
153
121
105
80
72
32
13
13
12
11
8
4
4
3
3
2
2
2
2
2
2
2
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human c- kit around the phosphorylation site of Tyrosine 936 (H-I-YP-S-N).
Specificity C-kit (phospho-Tyr936) Antibody AP08039PU detects endogenous levels of c-kit only when phosphorylated at Tyrosine 936.
Purification Immunoaffinity Chromatography.
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-KIT antibody (Mast/stem Cell Growth Factor Receptor) (pTyr936) (ABIN319288) anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr936) antibody
Background publications Blume-Jensen, Jiang, Hyman, Lee, OGorman, Hunter: "Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility." in: Nature genetics, Vol. 24, Issue 2, pp. 157-62, 2000 (PubMed).

Lowe: "Colipase stabilizes the lid domain of pancreatic triglyceride lipase." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 9-12, 1997 (PubMed).

Martin, Suggs, Langley, Lu, Ting, Okino, Morris, McNiece, Jacobsen, Mendiaz: "Primary structure and functional expression of rat and human stem cell factor DNAs." in: Cell, Vol. 63, Issue 1, pp. 203-11, 1990 (PubMed).