SNCA antibody (Synuclein, alpha) (Tyr136)

Details for Product anti-SNCA Antibody No. ABIN319339, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Alternatives
anti-Rat (Rattus) SNCA antibody for Cytometry by Time of Flight
Epitope
Tyr136
62
48
43
41
38
38
36
30
20
18
18
18
18
13
12
10
8
7
6
5
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
720
390
379
22
20
19
18
12
10
7
4
2
2
2
1
1
1
Host
Rabbit
414
284
36
10
4
2
Clonality
Polyclonal
Conjugate
This SNCA antibody is un-conjugated
32
31
26
12
12
10
9
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
Application
Immunofluorescence (IF), Western Blotting (WB)
569
329
195
194
125
108
79
78
26
26
21
17
13
10
7
3
2
2
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human alpha-Synuclein around the phosphorylation site of Tyrosine 136 (Q-D-Yp-E-P).
Specificity Antibody detects endogenous levels of total alpha-Synuclein protein.
Purification Immunoaffinity Chromatography
Alternative Name alpha-Synuclein / SNCA (SNCA Antibody Abstract)
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Gene ID 6622
NCBI Accession NP_000336
UniProt P37840
Research Area Neurology
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-SNCA antibody (Synuclein, alpha) (Tyr136) (ABIN319339) anti-Synuclein, alpha (SNCA) (Tyr136) antibody
 image for anti-SNCA antibody (Synuclein, alpha) (Tyr136) (ABIN319339) anti-Synuclein, alpha (SNCA) (Tyr136) antibody (Image 2)
Background publications Chen, Chang, Liao, Chao: "Humidity effect on the decay of second-order nonlinearity in thermally poled fused silica." in: Optics express, Vol. 14, Issue 25, pp. 12334-40, 2009 (PubMed).

Takahashi, Yamashita, Nagano, Nakamura, Ohmori, Avraham, Avraham, Yasuda, Matsumoto: "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42225-33, 2003 (PubMed).

Negro, Brunati, Donella-Deana, Massimino, Pinna: "Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 2, pp. 210-2, 2002 (PubMed).

Goldberg, Lansbury: "Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?" in: Nature cell biology, Vol. 2, Issue 7, pp. E115-9, 2000 (PubMed).