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Details for Product No. ABIN350240

Cofilin 1 (Non-Muscle) (CFL1) (pTyr140), (pSer156) antibody

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Antigen
Synonyms
CFL, CFL1, AA959946, Cof, cfl1, xac1, xac2, cfl, cb86, sb:cb86, zgc:56501, wu:fb18a04, wu:fk77b03, 12/8, ADF, ADF/cofilin, Adf, CG4254, Cadf, D-cof, D61, Dmel\\CG4254, T8, Tsr, cofilin, cofilin/ADF, c ... show more
Epitope
»Alternatives pTyr140, pSer156
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine), Monkey
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350240
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the phospho Y140 & S156 of human Cofilin-1 (Cofilin, non-muscle isoform) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse and monkey.
Isotype IgG
Specificity Appears to be specific for Cofilin-1.
Purity IgG
Alternative Name Cofilin-1 (Cofilin, non-muscle isoform)
Background Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Note: Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue specificity: Widely distributed in various tissues. Also known as: Cofilin, non-muscle isoform.
UniProt P23528
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. This antibody may also recognice the unphosphorylated form. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Ogawa, Tashima, Yumoto et al.: "Coding sequence of human placenta cofilin cDNA." in: Nucleic acids research, Vol. 18, Issue 23, pp. 7169, 1991 (PubMed).

Davidson, Haslam: "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+." in: The Biochemical journal, Vol. 301 ( Pt 1), pp. 41-7, 1994 (PubMed).

Nakano, Kanai-Azuma, Kanai et al.: "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family." in: Experimental cell research, Vol. 287, Issue 2, pp. 219-27, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Alternatives for antigen "Cofilin 1 (Non-Muscle) (CFL1)", type "Antibodies"
Hosts (108), (25), (3)
Reactivities (135), (82), (71), (24), (24), (13), (13), (12), (3)
Applications (93), (42), (42), (39), (24), (20), (7), (6), (3), (3), (3), (2), (2)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (22), (20), (13), (11), (9), (6), (6), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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