MAP-2 antibody

Details for Product No. ABIN350439
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Antigen
Synonyms p67, p67eIF2, MAP2A, MAP2B, MAP2C, MAP-2, Mtap-2, Mtap2, MAP2R, xmap2, MGC53131, a730034c02
Reactivity
Human
(162), (100), (99), (76), (35), (24), (19), (4), (3), (3), (3), (1)
Host
Rabbit
(107), (96), (18), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (7), (7), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(156), (69), (54), (53), (49), (44), (30), (30), (26), (21), (10), (3), (2), (2), (1)
Pubmed 8 references available
Quantity 500 μg
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Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350439
454.67 $
Plus shipping costs $45.00

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Immunogen A synthetic peptide from human MAP2 (Microtubule-associated protein 2, MAP-2, MAP 2, MAP2R) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for MAP-2.
Alternative Name MAP2
Background Regulates and organizes microtubules, may serve as a scaffolding protein for neuromodulatory activities.
Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Subcellular location: Cytoplasm, cytoskeleton.
Developmental stage: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development. Also known as: Microtubule-associated protein 2, MAP 2, MAP-2, MAP2R.
Research Area Stem Cells, Cytoskeleton
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Kosik, Orecchio, Bakalis et al.: "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles." in: Journal of neurochemistry, Vol. 51, Issue 2, pp. 587-98, 1988 (PubMed).

Dammerman, Yen, Shafit-Zagardo: "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles." in: Journal of neuroscience research, Vol. 24, Issue 4, pp. 487-95, 1990 (PubMed).

Albala, Kalcheva, Shafit-Zagardo: "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)." in: Gene, Vol. 136, Issue 1-2, pp. 377-8, 1994 (PubMed).

DeGiorgis, Jaffe, Moreira et al.: "Phosphoproteomic analysis of synaptosomes from human cerebral cortex." in: Journal of proteome research, Vol. 4, Issue 2, pp. 306-15, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Cantin, Yi, Lu et al.: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).

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