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Nerve Growth Factor Receptor (NGFR) antibody
| Antigen | Nerve Growth Factor Receptor (NGFR) |
| Synonyms | CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, MGC148470, NGFR, wu:fb38c02, wu:fc10h01, p75, LNGFR, RNNGFRR, nrh1, NRH1b, p75ntr, tnfrsf16, MGC131034 |
| Clonality | Monoclonal |
| Host |
 Alternatives Mouse |
| Application |
Alternatives Immunohistochemistry (IHC), Immunocytochemistry (ICC)
|
 |
3 references available |
| Catalog no. | ABIN350715 |
| Quantity | 150 µg (Variants) |
| Price | 413.33 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | p75NTR (ME20.4, low affinity NGF receptor) |
| Swiss-Prot | P08138 |
| Immunogen | Human melanoma cell lines |
| Format | Lyophilized |
| Isotype | IgG1 (Matching secondary antibodies) |
| Description | FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Also known as: Tumor necrosis factor receptor superfamily member 16, P08138, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, CD271 antigen, NGFR, TNFRSF16. |
| Specificity | Appears to be specific for p75NTR. |
Application Details
| Application Notes | Immunohistochemistry (IHC),Immunocytochemistry (ICC). A concentration of 2-10 µg/ml is recommended. The optimal working concentration should be determined by the end user. This antibody may also be used for immunoabsorptive purification of NGF-receptors. See also the eLab Book at the end of this page. |
| Storage | Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Restrictions | For Research Use only |
Publications
| Publications |
Zupan, Osborne, Smith et al.: "Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor." in: The Journal of biological chemistry, Vol. 264, Issue 20, pp. 11714-20, 1989 (PubMed).
Ross, Grob, Bothwell et al.: "Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 21, pp. 6681-5, 1984 (PubMed). Tremere, Pinaud, Grosche et al.: "Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species." in: Neuroreport, Vol. 11, Issue 10, pp. 2177-83, 2000 (PubMed). |
Alternatives
Alternatives for antigen "Nerve Growth Factor Receptor (NGFR)", type "Antibodies"
| Hosts | Mouse (34), Rabbit (21), Goat (7), Rat (3), Sheep (1) |
| Reactivities | Human (44), Rat (Rattus) (7), Cat (Feline) (6), Mouse (Murine) (6), Monkey (5), Dog (Canine) (4), Rabbit (3), Pig (Porcine) (2), Guinea Pig (1) |
| Applications | Western Blotting (WB) (43), Immunofluorescence (IF) (22), Flow Cytometry (FACS) (21), Immunohistochemistry (Frozen Sections) (IHC (fro)) (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), Immunohistochemistry (IHC) (14), ELISA (9), Immunoprecipitation (IP) (9), Enzyme Immunoassay (EIA) (6), Immunocytochemistry (ICC) (5), Functional Studies (Func) (2), ELISA (Detection) (1), Neutralization (Neut) (1), Radioimmunoassay (RIA) (1) |
| Conjugates | Biotin (2), APC (1), FITC (1), PE (1) |
| Epitopes | cytoplasmic domain (7), extracellular domain (2) |
