CUL9 antibody (C-Term)

Catalog No. ABIN356104

Product Details anti-CUL9 Antibody

Target: CUL9 (Cullin 9 (CUL9))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUL9 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: affinity purified

Immunogen: 17 amino acid synthetic peptide from near the carboxy terminus of human PARC.

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for CUL9

Target: CUL9 (Cullin 9 (CUL9))

Alternative Name: PARC/P53-associated Parkin-like Cytoplasmic Protein (CUL9 Products)

Synonyms: H7AP1 antibody, PARC antibody, RP3-330M21.2 antibody, parc antibody, 1810035I07Rik antibody, Cul-9 antibody, Parc antibody, mKIAA0708 antibody, RGD1562008 antibody, cullin-9 antibody, cullin 9 antibody, cullin-9 antibody, CUL9 antibody, LOC100083225 antibody, cul9 antibody, LOC100561099 antibody, Cul9 antibody

Background: PARC (p53 associated parkin like cytoplasmic protein) antibody directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines, RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.