Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) antibody

Details for Product No. ABIN357077
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Antigen
Synonyms KREMEN1, krm1, kremen, kremem1, KREMEN, KRM1, AV002070, Kremen, Krm1, si:ct737139.1, si:dkeyp-7c9.1
Epitope
N-Term
(21), (12), (6), (2), (2), (1), (1)
Reactivity
Human
(38), (11), (8), (2), (1)
Host
Rabbit
(36), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(34), (29), (12), (7), (4), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN357077
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Kremen.
Specificity This antibody detects Kremen at N-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name Kremen protein 1
Background Kremen is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains.
Alternate names: Dickkopf receptor, KREMEN, KREMEN1, KRM1, Kringle domain-containing transmembrane protein 1, Kringle-containing protein marking the eye and the nose
Molecular Weight 63,201 Da
Gene ID 83999
NCBI Accession NP_001034659
UniProt Q96MU8
Application Notes ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) antibody anti-Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) antibody
anti-Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) antibody (2) anti-Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) antibody (Image 2)
Background publications Kammeraat, Veldstra: "Characterization of succinate semialdehyde dehydrogenase from rat brain." in: Biochimica et biophysica acta, Vol. 151, Issue 1, pp. 1-10 (PubMed).

Mao, Wu, Davidson et al.: "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling." in: Nature, Vol. 417, Issue 6889, pp. 664-7, 2002 (PubMed).

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