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SOX2 antibody (SRY (Sex Determining Region Y)-Box 2)

Details for Product anti-SOX2 Antibody No. ABIN357439, Supplier: Log in to see
Antigen
  • ANOP3
  • anop3
  • cb236
  • lcc
  • MCOPS3
  • mcops3
  • Qscn6
  • Qsox
  • RGD1565646
  • rSOx
  • sox-2
  • Sox-2
  • SRY-box2
  • wu:fb83g04
  • wu:fc14d07
  • Xsox-2
  • ysb
  • zgc:65860
  • zgc:77389
Reactivity
Human
375
132
57
19
16
10
9
8
7
6
5
4
3
3
2
2
1
1
Host
Rabbit
278
100
7
4
Clonality
Polyclonal
Conjugate
This SOX2 antibody is un-conjugated
18
17
15
14
11
11
7
5
4
4
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
263
156
93
81
81
74
59
52
12
7
6
5
4
3
2
2
2
2
1
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a recombinant protein of human SOX2.
Isotype Ig
Specificity This antibody detects SOX2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name SOX2 (SOX2 Antibody Abstract)
Background SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.Synonyms: ANOP3, MCOPS3, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, Transcription factor SOX-2
Molecular Weight 34310 Da MW based on amino acid sequence. Theoretical pI: 9.74.
Gene ID 6657, 9606
UniProt P48431
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Application Notes ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (ABIN357439) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody
Background publications Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).