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Details for Product No. ABIN357439

SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

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Antigen
Synonyms ANOP3, MCOPS3, RGD1565646, Qsox, rSOx, Qscn6, Sox-2, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389, SRY-box2, Xsox-2, anop3, mcops3, sox-2
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN357439
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a recombinant protein of human SOX2.
Specificity This antibody detects SOX2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name SOX2
Background SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.
Alternate names: ANOP3, MCOPS3, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, Transcription factor SOX-2
Molecular Weight 34310 Da MW based on amino acid sequence. Theoretical pI: 9.74.
Gene ID 6657
NCBI Accession 9606
UniProt P48431
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Application Notes ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Reményi, Lins, Nissen et al.: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts (126), (30), (4)
Reactivities (147), (62), (41), (22), (21), (20), (17), (12), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Applications (118), (45), (37), (27), (23), (18), (12), (11), (10), (5), (4), (1)
Conjugates (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (26), (7), (6), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
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