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Details for Product No. ABIN358131

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (pTyr996) antibody

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Antigen
Synonyms FLK1, CD309, VEGFR, VEGFR2, Vegfr-2, FLK-1, flk-1, FLK/KDR, vegfr-2, KDR
Epitope
»Alternatives pTyr996
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN358131
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y996 of human KDR/FLK1
Specificity This antibody detects CD309 (KDR/Flk-1) pTyr996.
Purification Affinity chromatography on Protein G
Alternative Name CD309 / VEGFR-2 / Flk-1
Background KDR (FLK1) is a receptor for VEGF or VEGFC. This protein has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
Alternate names: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Molecular Weight 151527 Da
Gene ID 3791
NCBI Accession 9606
UniProt P35968
Research Area Cytokines, Receptors
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).

Le Boeuf, Houle, Huot: "Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 39175-85, 2004 (PubMed).

Wittko, Schänzer, Kuzmichev et al.: "VEGFR-1 regulates adult olfactory bulb neurogenesis and migration of neural progenitors in the rostral migratory stream in vivo." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 27, pp. 8704-14, 2009 (PubMed).

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts (377), (78), (36), (3), (3), (2)
Reactivities (417), (261), (158), (18), (17), (14), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Applications (354), (156), (136), (121), (81), (77), (40), (38), (24), (20), (8), (7), (4), (4), (2), (2), (1)
Conjugates (35), (6), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (46), (39), (39), (26), (19), (16), (12), (11), (10), (7), (7), (6), (6), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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