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RICTOR antibody (RPTOR Independent Companion of MTOR, Complex 2) (N-Term)

Details for Product anti-RICTOR Antibody No. ABIN359477, Supplier: Log in to see
Antigen
  • 4921505C17Rik
  • 6030405M08Rik
  • AVO3
  • AW492497
  • D530039E11Rik
  • Fyb
  • mAVO3
  • PIA
Alternatives
anti-Human RICTOR antibody for Western Blotting
Epitope
N-Term
26
24
13
13
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
Reactivity
Human
141
46
12
7
6
2
1
1
Host
Rabbit
92
32
19
Clonality
Polyclonal
Conjugate
This RICTOR antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
94
74
58
25
21
12
11
7
6
5
2
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Rictor.
Isotype Ig
Specificity This antibody detetcs Rictor at N-term.
Purification Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RICTOR (RICTOR Antibody Abstract)
Background RICTOR and MTOR (FRAP1) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.Synonyms: KIAA1999, Rapamycin-insensitive companion of mTOR, mAVO3
Molecular Weight 192087 Da
Gene ID 253260, 9606
UniProt Q6R327
Research Area Signaling
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA 1: 1,000. Immunohistochemistry 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-RICTOR antibody (RPTOR Independent Companion of MTOR, Complex 2) (N-Term) (ABIN359477) Formalin-fixed and paraffin-embedded human Lymph tissue reacted with Rictor antibody ...
Background publications Gao, Wu, Spencer, Johnson, Bazer et al.: "Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ..." in: Biology of reproduction, Vol. 81, Issue 1, pp. 87-100, 2009

Pearce, Huang, Boudeau, Paw?owski, Wullschleger, Deak, Ibrahim, Gourlay, Magnuson, Alessi: "Identification of Protor as a novel Rictor-binding component of mTOR complex-2." in: The Biochemical journal, Vol. 405, Issue 3, pp. 513-22, 2007

Jacinto, Facchinetti, Liu, Soto, Wei, Jung, Huang, Qin, Su: "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity." in: Cell, Vol. 127, Issue 1, pp. 125-37, 2006

Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." in: Genes & development, Vol. 20, Issue 20, pp. 2820-32, 2006