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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody

Details for Product No. ABIN360059, Supplier: Log in to see
Antigen
  • AA959795
  • bHLHe78
  • hif-1a
  • HIF-1A
  • HIF-1alpha
  • HIF1
  • HIF1-alpha
  • HIF1-ALPHA
  • hif1a
  • HIF1alpha
  • MOP1
  • PASD8
Epitope
C-Term
84
58
39
39
20
18
15
14
13
13
13
13
13
10
8
8
6
6
6
6
6
6
5
5
5
5
5
5
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
583
263
202
118
85
69
61
56
50
50
38
36
22
19
18
17
12
12
1
1
1
1
1
1
1
1
Host
Rabbit
377
277
2
Clonality
Polyclonal
Conjugate
Un-conjugated
51
33
32
26
25
25
17
17
14
14
12
12
6
6
6
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
498
222
205
191
177
157
102
92
49
15
11
11
10
7
6
4
4
3
3
2
2
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HIF1A.
Isotype Ig
Specificity This antibody reacts to HIF1alpha.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name HIF1A / HIF1 alpha (HIF1A Antibody Abstract)
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT).Synonyms: ARNT-interacting protein, BHLHE78, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1 alpha, Hypoxia-inducible factor 1 alpha, Member of PAS protein 1
Gene ID 3091, 9606
UniProt Q16665
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody (ABIN360059) anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody
Background publications Alexandru, Graumann, Smith, Kolawa, Fang, Deshaies: "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover." in: Cell, Vol. 134, Issue 5, pp. 804-16, 2008 (PubMed).

Favaro, Nardo, Persano, Masiero, Moserle, Zamarchi, Rossi, Esposito, Plebani, Sattler, Mann, Mueller-Klieser, Ciminale, Amadori, Indraccolo: "Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death." in: The American journal of pathology, Vol. 173, Issue 4, pp. 1186-201, 2008 (PubMed).