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Details for Product No. ABIN361724

Toll-Like Receptor 4 (TLR4) (AA 420-435) antibody

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Antigen
Synonyms ARMD10, CD284, TLR-4, TOLL, Lps, Ly87, Ran/M1, Rasl2-8
Epitope
»Alternatives AA 420-435
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN361724
Quantity 100 µg
Price
333.30 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Developed against a synthetic peptide corresponding to AA 420-435 of human TLR4.
Specificity Detects approx. 75-80 kDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
Purification Affinity Purified
Alternative Name TLR4
Background Synonyms:
ARMD10, CD284, TLR 4, TOLL, Toll like receptor 4
The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Amount this family of receptors, TLR2 and TLR4 have beenmost studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling. The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90 kDa.
Gene ID 7099
NCBI Accession NP_612564.1
UniProt O00206
Research Area Immunology, Innate Immunity, Adaptive Immunity, Atherosclerosis, Signaling, Inflammation, Cell Signaling
Application Notes Recommended Dilution: 1-3 µg/mL (WB), 1:50 (IHC)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, 0.05 % BSA, 0.05 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Kammeraat, Veldstra: "Characterization of succinate semialdehyde dehydrogenase from rat brain." in: Biochimica et biophysica acta, Vol. 151, Issue 1, pp. 1-10 (PubMed).

Medzhitov, Preston-Hurlburt, Janeway: "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity." in: Nature, Vol. 388, Issue 6640, pp. 394-7, 1997 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Takeuchi, Hoshino, Kawai et al.: "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components." in: Immunity, Vol. 11, Issue 4, pp. 443-51, 1999 (PubMed).

Poltorak, Ricciardi-Castagnoli, Citterio et al.: "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 5, pp. 2163-7, 2000 (PubMed).

Chuang, Ulevitch: "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells." in: Biochimica et biophysica acta, Vol. 1518, Issue 1-2, pp. 157-61, 2001 (PubMed).

Alternatives for antigen "Toll-Like Receptor 4 (TLR4)", type "Antibodies"
Hosts (141), (126), (20), (5)
Reactivities (222), (88), (35), (25), (24), (21), (19), (12), (4), (3), (2), (2), (1), (1), (1)
Applications (149), (141), (64), (62), (43), (31), (28), (18), (17), (10), (9), (7), (6), (3), (2), (1), (1), (1), (1)
Conjugates (30), (28), (18), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (23), (13), (9), (9), (7), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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