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IGF1R antibody (pTyr1166)
IGF1R
Reactivity: Human, Mouse, Rat
WB, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IGF1R Antibody
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Target
See all IGF1R Antibodies
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Binding Specificity
All epitopes for IGF1R antibodies
pTyr1166
Reactivity
All reactivities for IGF1R antibodies
Human, Mouse, Rat
Host
All hosts for IGF1R antibodies
Rabbit
Clonality
All clonalities for IGF1R antibodies
Polyclonal
Conjugate
All conjugates for IGF1R antibodies
This IGF1R antibody is un-conjugated
Application
All applications for IGF1R antibodies
Western Blotting (WB), Immunofluorescence (IF)
Specificity
The antibody detects endogenous level of IGF-1R only when phosphorylated at tyrosine 1165/tyrosine1166.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pTyr 1165, pTyr1166 (T-D-Y (p) -Y (p) -R-K) derived from Human IGF-1R . Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western blotting: 1:500-1:1000 Immunofluorescence: 1:100-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
References for anti-IGF1R antibody (ABIN362040)
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Han, Quirion, Zheng : "WITHDRAWN: Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric Oxide Synthase. " in: Biochemical and biophysical research communications , (2011 ) (PubMed ).
Target Details for IGF1R
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Target
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Alternative Name
IGF-1R (IGF1R Products )
Synonyms
CMT2N antibody, CD221 antibody, IGFIR antibody, IGFR antibody, JTK13 antibody, IGFIRC antibody, IGFR1 antibody, IGF-1R antibody, IGF1R antibody, DKFZp469I0618 antibody, igf-1r antibody, xIGF-1R antibody, xIGFR antibody, xigf1r antibody, A330103N21Rik antibody, D930020L01 antibody, hyft antibody, igf-ir antibody, IGF-IR antibody, IGF-IRb antibody, wu:fb03h06 antibody, IGF-IRa antibody, sb:eu1090 antibody, wu:fi20b10 antibody, alanyl-tRNA synthetase antibody, insulin like growth factor 1 receptor antibody, insulin-like growth factor 1 receptor antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I receptor antibody, insulin like growth factor 1 receptor S homeolog antibody, insulin-like growth factor 1b receptor antibody, insulin-like growth factor 1a receptor antibody, AARS antibody, IGF1R antibody, Igf1r antibody, igf1r antibody, Igf1 antibody, LOC780503 antibody, LOC100136427 antibody, igf1r.S antibody, igf1rb antibody, igf1ra antibody
Background
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Molecular Weight
95 kDa
NCBI Accession
NP_000866
UniProt
P08069
Pathways
RTK Signaling , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagy
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