The antibody detects endogenous level of total Glutamate receptor 2 (Precursor) protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Peptide sequence around AA 878-882 (I-E-S-V-K) derived from Human Glutamate receptor 2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.