Klra3
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 3 (Klra3))
Reactivity
Mouse
Host
Hamster
Clonality
Monoclonal
Conjugate
This Klra3 antibody is conjugated to PE
Application
Flow Cytometry (FACS)
Specificity
This antibody is specific to an epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants. The antibody stains ~ 90 % of NK1.1+CD3- splenocytes, and ~ 6 % of CD8+ spleen cells from C57BL/6 mice. (Ref.1) The antibody also stains 30-80 % of NK1.1+CD3-splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Characteristics
Synonyms: Ly49C, Ly49F, Ly49H, Ly49I, Ly-49H, Ly-49C, Ly-49F, Ly-49I, Klra3, Klra9, Klra8, Klra6, T cellsurface glycoprotein Ly 49C, T cell surface glycoprotein Ly 49F, T cell surface glycoproteinLy 49H, T cell surface glycoprotein Ly 49I, Killer cell lectin-like receptor
Flow Cytometry: < / = 0.2 μg/10^6 cells. (Ref.1,3) Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.1 mg/mL
Buffer
PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date
12 months
Target
Klra3
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 3 (Klra3))
Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. (Ref.2) These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.Synonyms: Killer cell lectin-like receptor, Klra3, Klra6, Klra8, Klra9, Ly-49C, Ly-49F, Ly-49H, Ly-49I, Ly49C, Ly49F, Ly49H, Ly49I, T cell surface glycoprotein Ly 49C, T cell surface glycoprotein Ly 49F, T cell surface glycoprotein Ly 49H, T cell surface glycoprotein Ly 49I