Recognizes the ~15 kDa alpha-Synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Cross-Reactivity (Details)
Species reactivity (expected):Bovine, Canine, Human, Mouse and non-Human Primates. Species reactivity (tested):Rat.
Purification
Affinity Chromatography.
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha Synuclein.
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005, Masliah et al., 2005).Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1