anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody

Details for Product No. ABIN374464
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Antigen
Synonyms ANTXR1, ATR, TEM8, 2310008J16Rik, 2810405N18Rik, Antrx1, Tem8
Epitope
C-Term
(16), (15), (7), (6), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(100), (40), (35), (13), (12), (1)
Host
Goat
(95), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(58), (40), (21), (21), (20), (13), (12), (5), (3), (2), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN374464
357.50 $
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Immunogen Peptide with sequence C-RAPPPSRPPPRPSV, from the C Terminus of the protein sequence
Specificity This antibody reacts to Anthrax toxin receptor 1.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Bovine, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name Anthrax Toxin Receptor 1
Background TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has also been shown to be a docking protein or receptor for Bacillus anthracistoxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor(EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
Gene ID 84168, 9606
UniProt Q9H6X2
Research Area Toxicology, Receptors
Application Notes Peptide ELISA: 1/64000. Western blot: 0.2 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody
Background publications Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

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