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Activin Receptor Type 1 (ACRV1) (Internal Region) antibody

Details for Product No. ABIN374913, Supplier: Log in to see
Antigen
Epitope
Internal Region
3
3
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
9
8
3
1
1
Host
Goat
8
1
1
Clonality
Polyclonal
Application
Western Blotting (WB)
10
8
6
1
Supplier
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Immunogen Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence
Specificity This antibody reacts to ACVR1.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Background Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4. Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones inlude activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors:ACVR1, ACVR1B, and ACVR1C Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.Synonyms: ACRV1A, ACVRLK2, ALK2, Activin receptor type IA, Activin receptor-like kinase 2, SKR1, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I
Gene ID 90, 9606
UniProt Q04771
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.3 - 1 μg/mL. Immunohistochemistry on paraffin sections: 4 - 6 μg/mL.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody (ABIN374913) anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody
 image for anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody (ABIN374913) anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody (Image 2)
Background publications Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva." in: Nature genetics, Vol. 38, Issue 5, pp. 525-7, 2006 (PubMed).