LRRK2 antibody (C-Term)

Catalog No. ABIN387804

Cited in 2+ publications. The Mouse Monoclonal anti-LRRK2 antibody (Clone 133AT1218) (ABIN387804) specifically detects LRRK2 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for LRRK2 antibody (C-Term) (ABIN387804)

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRRK2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 133AT1218

Product Details anti-LRRK2 Antibody

Binding Specificity: C-Term

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This PARK8 (LRRK2) antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.

Isotype: IgG1

Application Details

Application Notes: IHC: 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LRRK2 antibody (ABIN387804)

Ortiz-Ortiz, Morán, Ruiz-Mesa, Niso-Santano, Bravo-SanPedro, Gómez-Sánchez, González-Polo, Fuentes: "Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells." in: Neuroscience letters, Vol. 468, Issue 2, pp. 120-4, (2009) (PubMed).

Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." in: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

Target Details for LRRK2

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Alternative Name: PARK8 (LRRK2)

Background: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Molecular Weight: 286103

Gene ID: 120892

NCBI Accession: NP_940980

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development