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Details for Product No. ABIN387883

DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) (N-Term), (AA 31-61) antibody

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Antigen
Synonyms DNMT3A2, M.HsaIIIA, DNMT3A
Epitope
»Alternatives N-Term, AA 31-61
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN387883
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-61 AA from the N-terminal region of human Dnmt3a.
Clone RB15267
Isotype Ig
Specificity This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39~68 amino acids from the N-terminal region of human Dnmt3a.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DNMT3A
Background CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Synonyms: DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA
Molecular Weight 101558 DA
Gene ID 1788
UniProt Q9Y6K1
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Robertson, Uzvolgyi, Liang et al.: "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors." in: Nucleic acids research, Vol. 27, Issue 11, pp. 2291-8, 1999 (PubMed).

Xie, Wang, Okano et al.: "Cloning, expression and chromosome locations of the human DNMT3 gene family." in: Gene, Vol. 236, Issue 1, pp. 87-95, 1999 (PubMed).

Alternatives for antigen "DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A)", type "Antibodies"
Hosts (73), (15), (3), (2)
Reactivities (87), (34), (22), (15), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (78), (29), (17), (16), (11), (10), (9), (7), (3), (3)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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