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APOBEC3G antibody (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G) (AA 352-384)

Details for Product anti-APOBEC3G Antibody No. ABIN388143, Supplier: Log in to see
Antigen
  • A3G
  • ARCD
  • ARP-9
  • ARP9
  • CEM-15
  • CEM15
  • bK150C2.7
  • dJ494G10.1
Epitope
AA 352-384, C-Term
52
36
15
15
13
11
8
8
4
3
3
2
2
2
2
1
1
1
Reactivity
Human
171
5
5
Host
Rabbit
130
21
20
Clonality (Clone)
Polyclonal ()
Conjugate
This APOBEC3G antibody is un-conjugated
11
11
11
10
10
10
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
141
100
66
19
11
8
5
1
1
Supplier
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Immunogen This APOBEC3G (CEM15) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-384 AA from the C-terminal region of human APOBEC3G (CEM15).
Clone RB01788
Isotype Ig
Specificity This CEM15 antibody is generated from mice immunized with KLH conjugated synthetic peptides corresponding to C-terminal of human CEM15.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name APOBEC3G (CEM15) (APOBEC3G Antibody Abstract)
Background CEM15 is a member of the cytidine deaminase family. It is the product of one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. CEM15 has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Synonyms: DNA dC->dU-editing enzyme APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, APOBEC-related protein, ARP-9, CEM15, CEM-15, APOBEC3G, MDS019
Molecular Weight 46408 DA
Gene ID 60489
Research Area Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-APOBEC3G antibody (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G) (AA 352-384) (ABIN388143) The anti-CEM15 Pab (ABIN388143) is used in Western blot to detect CEM15 in A375 cell ...
Immunohistochemistry (IHC) image for anti-APOBEC3G antibody (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G) (AA 352-384) (ABIN388143) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Kao, Khan, Miyagi et al.: "The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity." in: Journal of virology, Vol. 77, Issue 21, pp. 11398-407, 2003 (PubMed).

Stopak, de Noronha, Yonemoto et al.: "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability." in: Molecular cell, Vol. 12, Issue 3, pp. 591-601, 2003 (PubMed).

Mangeat, Turelli, Caron et al.: "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts." in: Nature, Vol. 424, Issue 6944, pp. 99-103, 2003 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Wedekind, Dance, Sowden et al.: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, 2003 (PubMed).