Cyclin D1 (CCND1) (AA 147-175), (Center) antibody

Details for Product No. ABIN389145
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Antigen
Epitope
AA 147-175, Center
(44), (21), (15), (11), (8), (7), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(260), (97), (95), (28), (16), (9), (7), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(225), (73), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(11), (9), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(241), (87), (82), (55), (54), (39), (34), (33), (20), (19), (11), (3), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN389145
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Immunogen This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 AA from the Central region of human CCND1.
Clone RB14995
Isotype Ig
Specificity This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154~183 amino acids from the Center region of human CCND1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CCND1
Background CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Synonyms: CCND1 protein, Cyclin D1, isoform CRA_c, cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1),mRNA, Cyclin D1, PRAD1: parathyroid adenomatosis 1, CCND1
Molecular Weight 33729 DA
Gene ID 595
UniProt Q6FI00
Research Area Cancer, Cell Cycle
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin D1 (CCND1) (AA 147-175), (Center) antibody Western blot analysis of CCND1 (arrow) using rabbit polyclonal CCND1 Antibody (Center) (ABIN389145). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CCND1 gene (Lane 2) (Origene Technologies).
Background publications Caldon, Swarbrick, Lee et al.: "The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini." in: Cancer research, Vol. 68, Issue 8, pp. 3026-36, 2008 (PubMed).

Marsit, Black, Posner et al.: "A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neck." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 8, pp. 2371-7, 2008 (PubMed).

He, Council, Feng et al.: "UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes." in: Cancer research, Vol. 68, Issue 10, pp. 3752-8, 2008 (PubMed).

Validation Images
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