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Details for Product No. ABIN389194

Indoleamine 2,3-Dioxygenase 1 (IDO1) (C-Term), (AA 374-403) antibody

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Antigen
Synonyms IDO, IDO-1, INDO, Ido, Indo, ido, indo, cd107b, IDO1
Epitope
»Alternatives C-Term, AA 374-403
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN389194
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This INDO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-403 AA from the C-terminal region of human INDO.
Clone RB15061
Isotype Ig
Specificity This INDO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374~403 amino acids from the C-terminal region of human INDO.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name INDO
Background Gamma-interferon (IFNG, MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO, EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM]
Synonyms: Indoleamine 2,3-dioxygenase, IDO, EC 1.13.11.52, Indoleamine-pyrrole 2,3-dioxygenase, INDO, IDO
Molecular Weight 45326 DA
Gene ID 3620
UniProt P14902
Research Area Stem Cells, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Scheler, Wenzel, Tüting et al.: "Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?" in: The American journal of pathology, Vol. 171, Issue 6, pp. 1936-43, 2007 (PubMed).

Maghzal, Thomas, Hunt et al.: "Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12014-25, 2008 (PubMed).

Alternatives for antigen "Indoleamine 2,3-Dioxygenase 1 (IDO1)", type "Antibodies"
Hosts (48), (34), (8), (3), (1)
Reactivities (82), (34), (20), (18), (12), (12)
Applications (78), (44), (22), (16), (12), (11), (10), (5), (4), (4), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (7), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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