ATM antibody (Ataxia Telangiectasia Mutated) (pSer1981)

Details for Product anti-ATM Antibody No. ABIN389888, Supplier: Log in to see
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated homolog (human)
  • tefu
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • AaeL_AAEL014900
  • MGYG_07634
  • PGTG_14279
  • Atm
  • LOC100349299
Alternatives
anti-Hamster ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer1981
88
40
17
16
16
15
8
8
6
6
6
6
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
359
158
78
27
8
1
1
1
1
Host
Rabbit
233
99
17
9
3
Clonality (Clone)
Polyclonal ()
Conjugate
This ATM antibody is un-conjugated
12
11
10
9
6
6
5
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Dot Blot (DB), Immunofluorescence (IF)
220
126
110
88
85
72
59
45
27
20
13
6
4
4
2
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This Phospho-ATM-pS1981 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
Clone RB8121
Isotype Ig
Specificity This Phospho-ATM-pS1981 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ATM (ATM Antibody Abstract)
Background ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.
Synonyms: Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T, mutated, ATM
Molecular Weight 350644 DA
Gene ID 472
UniProt Q13315
Research Area Cell Signaling, Cell Cycle, Phospho-specific antibodies, Cell Structure
Pathways p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Application Notes DB = 1:500, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody (ABIN389888) Dot blot analysis of anti-Phospho-ATM-pS1981 Antibody (ABIN389888) on nitrocellulose ...
Immunofluorescence (IF) image for anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody (ABIN389888) Confocal immunofluorescent analysis ofPhospho-ATM-pS1981 Antibody (ABIN389888) with H...
Background publications Brunet, Gutiérrez-Enríquez, Torres, Bérez, Sanjosé, Galceran, Izquierdo, Menéndez, Gumà, Borràs: "ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations." in: Clinical genetics, Vol. 73, Issue 5, pp. 465-73, 2008 (PubMed).

Tsai, Chung, Takahashi, Xu, Hu: "Functional interaction between FOXO3a and ATM regulates DNA damage response." in: Nature cell biology, Vol. 10, Issue 4, pp. 460-7, 2008 (PubMed).

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