anti-FOXO4 antibody (Forkhead Box O4) (AA 44-73)

Details for Product anti-FOXO4 Antibody No. ABIN390133
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Antigen
Synonyms FOXO4, foxo4, AFX, AFX1, MLLT7, Afxh, Mllt7, afx, RGD1561201
Epitope
AA 44-73, N-Term
(35), (33), (21), (21), (10), (9), (7), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(234), (136), (92), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(216), (17), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
This FOXO4 antibody is un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(187), (97), (80), (34), (33), (30), (20), (6), (4), (3), (1), (1)
Pubmed 5 references available
Quantity 400 μL
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Immunogen This MLLT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 AA from the N-terminal region of human MLLT7.
Clone RB2253
Isotype Ig
Specificity This MLLT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~81 amino acids from the N-terminal region of human MLLT7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MLLT7 (FOXO4 Antibody Abstract)
Background The MLLT7 (Mixed-lineage leukemia translocated to 7) protein is a forkhead transcription factor that activates apoptosis by inducing the BCL-6 transcriptional repressor. MLL-MLLT7 fusion protein transformw myeloid progenitors and impairs forkhead protein function. MLLT7 is a target of the phosphatidylinositol 3-kinase/PKB insulin signaling pathway and the AMP-activated protein kinase-dependent pathway.
Molecular Weight 53757 DA
Gene ID 4303
UniProt P98177
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Forkhead Box O4 (FOXO4) (AA 44-73), (N-Term) antibody MLLT7 Antibody (R59) (ABIN390133) western blot analysis in mouse heart tissue lysates...
anti-Forkhead Box O4 (FOXO4) (AA 44-73), (N-Term) antibody (2) MLLT7 antibody (N-term) (ABIN390133)immunohistochemistry analysis in formalin fixed a...
Background publications Crossley: "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1." in: Journal of leukocyte biology, Vol. 74, Issue 4, pp. 583-92, 2003 (PubMed).

Tang, Lasky: "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30125-35, 2003 (PubMed).

So, Cleary: "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6542-52, 2002 (PubMed).

Kops, Medema, Glassford et al.: "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors." in: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2025-36, 2002 (PubMed).

Tang, Dowbenko, Jackson et al.: "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 14255-65, 2002 (PubMed).

Validation Images
Catalog No. ABIN390133
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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