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Details for Product No. ABIN391642

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (C-Term), (AA 705-736) antibody

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Antigen
Synonyms ADAMTS-2, ADAMTS-4, ADMP-1, ADAM-TS4, mKIAA0688, 3830423K05, ADAMTS4, DKFZp469J0817, ADAMTS13, ADAMTS5, ADAMTS-11
Epitope
»Alternatives C-Term, AA 705-736
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN391642
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 AA from the C-terminal region of human ADAMTS4.
Clone RB18037
Isotype Ig
Specificity This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713~743 amino acids from the C-terminal region of human ADAMTS4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADAMTS4
Background ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Synonyms: ADMP-1, Aggrecanase-1, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAMTS-4, ADAM-TS 4, ADAM-TS4, ADAMTS4, KIAA0688
Molecular Weight 90225 DA
Gene ID 9507
UniProt O75173
Research Area Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Tortorella, Pratta, Liu et al.: "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25791-7, 2000 (PubMed).

Alternatives for antigen "ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4)", type "Antibodies"
Hosts (71), (3), (2)
Reactivities (63), (28), (21), (3), (1), (1)
Applications (42), (25), (14), (12), (10), (8), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (7), (4), (2), (2), (2), (2), (1), (1), (1), (1)
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