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ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (C-Term), (AA 705-736) antibody

Details for Product No. ABIN391642
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Antigen
Synonyms ADAMTS-2, ADAMTS-4, ADMP-1, ADAM-TS4, mKIAA0688, 3830423K05, ADAMTS4, DKFZp469J0817, ADAMTS13, ADAMTS5, ADAMTS-11
Epitope
C-Term, AA 705-736
(24), (7), (6), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(73), (28), (22), (2), (1), (1)
Host
Rabbit
(78), (5), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (26), (21), (12), (11), (10), (4), (4), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN391642
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 AA from the C-terminal region of human ADAMTS4.
Clone RB18037
Isotype Ig
Specificity This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713~743 amino acids from the C-terminal region of human ADAMTS4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADAMTS4
Background ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Synonyms: ADMP-1, Aggrecanase-1, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAMTS-4, ADAM-TS 4, ADAM-TS4, ADAMTS4, KIAA0688
Molecular Weight 90225 DA
Gene ID 9507
UniProt O75173
Research Area Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (C-Term), (AA 705-736) antibody Western blot analysis of anti-ADAMTS4 Antibody (C-term) (ABIN391642) in mouse cerebellum tissue lysates (35 µg/lane). ADAMTS4 (arrow) was detected using the purified polyclonal antibody.
Product cited in: Lee, Lee, Gil et al.: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." in: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, 2014 (PubMed).

Background publications Tortorella, Pratta, Liu et al.: "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25791-7, 2000 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391642
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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