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CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 230-260)

Details for Product anti-CDK1 Antibody No. ABIN391742, Supplier: Log in to see
Antigen
  • 5363
  • cdc
  • cdc-2
  • cdc2
  • Cdc2
  • CDC2
  • cdc2-a
  • Cdc2a
  • CDC2A
  • CDC2AAT
  • cdc2Dm
  • cdc2x1.1
  • cdc28a
  • CDC28A
  • CDCDm
  • Cdk-1
  • Cdk1
  • CDK1
  • cdk1
  • CDK1/CDC2
  • CDK2
  • CDKA1
  • CDKA;1
  • cell division control 2
  • CG5363
  • CYCLIN-DEPENDENT KINASE A;1
  • Dcdc2
  • dCdk1
  • Dmcdc2
  • Dm cdc2
  • DmCdc2
  • DmCdk1
  • Dmel\\CG5363
  • group 4
  • l(2)31Eh
  • p34
  • p34cdc2
  • P34CDC2
  • POL3
  • pold
  • PSTAIR
  • wu:fc30e01
  • xcdc2
  • zgc:92032
Alternatives
anti-Human CDK1 antibody for Immunocytochemistry
Epitope
AA 230-260, C-Term
95
73
48
33
32
28
20
19
18
15
14
14
14
14
14
8
7
6
5
5
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
669
287
256
45
36
30
29
28
22
22
10
9
7
5
5
5
4
2
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
507
202
Clonality (Clone)
Polyclonal ()
Conjugate
This CDK1 antibody is un-conjugated
29
25
23
19
16
16
7
7
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Western Blotting (WB)
578
270
169
130
105
81
56
48
42
38
10
10
7
6
6
2
1
1
1
1
Supplier
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Immunogen This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 AA from the C-terminal region of human CDC2 (CDK1).
Clone RB3126
Isotype Ig
Specificity This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238~267 amino acids from the C-terminal region of human CDK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDC2 (CDK1) (CDK1 Antibody Abstract)
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: Cell division control protein 2 homolog, p34 protein kinase, Cyclin-dependent kinase 1
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 230-260) (ABIN391742) Western blot analysis of anti-CDK1 Pab (ABIN391742) in A375 cell lysate. CDK1 (arrow)...
Background publications Chow, Siu, Ho, Ma, Ho, Poon: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

Nozoe, Honda, Inutsuka, Korenaga: "p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma." in: Journal of cancer research and clinical oncology, Vol. 129, Issue 9, pp. 498-502, 2003 (PubMed).

Margottin-Goguet, Hsu, Loktev, Hsieh, Reimann, Jackson: "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase." in: Developmental cell, Vol. 4, Issue 6, pp. 813-26, 2003 (PubMed).

Yuan, Xie, Chen: "Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis." in: Journal of virology, Vol. 77, Issue 3, pp. 2063-70, 2003 (PubMed).

Manes, Zheng, Tognin, Woodard, Marchisio, Languino: "Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration." in: The Journal of cell biology, Vol. 161, Issue 4, pp. 817-26, 2003 (PubMed).