Cyclin-Dependent Kinase 1 (CDK1) (AA 1-30), (Thr14) antibody

Details for Product No. ABIN391744
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Antigen
Synonyms
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc ... show more
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, PSTAIR, cdc-2, cdc2-a, cdc28a, cdc2x1.1, p34cdc2, xcdc2, CDC2A, CDC2AAT, CDK2, CDKA1, CDKA;1, CYCLIN-DEPENDENT KINASE A;1, cell division control 2, POL3, pold show less
Epitope
AA 1-30, Thr14
(64), (52), (52), (28), (19), (18), (17), (13), (12), (8), (7), (7), (6), (6), (6), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(478), (249), (236), (45), (37), (30), (27), (27), (16), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(394), (124)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(21), (15), (15), (9), (9), (9), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(430), (198), (115), (109), (64), (63), (60), (46), (27), (21), (10), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391744
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Immunogen This CDK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from human CDK1.
Clone RB07952
Isotype Ig
Specificity This CDK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding T14 of human CDK1.
Predicted Reactivity Cow (Bovine),Chicken,Fruit Fly (Drosophila melanogaster),Mouse (Murine),Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDK1
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: V-abl Abelson murine leukemia viral oncogene homolog 1, ABL1
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 1-30), (Thr14) antibody Western blot analysis of CDK1(arrow) using rabbit polyclonal CDK1 Antibody (T14) (ABIN391744). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CDK1 gene (Lane 2) (Origene Technologies).
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 1-30), (Thr14) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDK1 Antibody (T14) (ABIN391744), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

Shapira, Ben-Izhak, Bishara et al.: "Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma." in: Cancer, Vol. 100, Issue 8, pp. 1615-21, 2004 (PubMed).

Krämer, Mailand, Lukas et al.: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004 (PubMed).

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