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RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 458-488)

Details for Product anti-RIPK2 Antibody No. ABIN392274, Supplier: Log in to see
Antigen
  • RIPK2
  • 2210420D18Rik
  • CARD3
  • CARDIAK
  • CCK
  • D4Bwg0615e
  • RICK
  • RIP2
  • GIG30
  • receptor-interacting serine-threonine kinase 2
  • receptor (TNFRSF)-interacting serine-threonine kinase 2
  • RIPK2
  • LOC100223072
  • Ripk2
Alternatives
anti-Human RIPK2 antibody for Western Blotting
Epitope
AA 458-488, C-Term
27
13
8
8
7
5
5
5
5
4
3
2
2
2
2
2
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
139
55
33
5
5
4
3
3
2
2
1
Host
Rabbit
120
16
5
Clonality (Clone)
Polyclonal ()
Conjugate
This RIPK2 antibody is un-conjugated
6
5
4
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
130
67
47
23
20
18
6
3
3
2
1
Options
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Immunogen This RIPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-488 AA from the C-terminal region of human RIPK2.
Clone RB03318
Isotype Ig
Specificity This RIPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~496 amino acids from the C-terminal region of human RIPK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RIPK2 (RIPK2 Antibody Abstract)
Background RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Synonyms: Receptor-interacting serine/threonine protein kinase 2, RIP-like interacting CLARP kinase, Receptor-interacting protein 2, RIP-2, CARD-containing interleukin-1 beta converting enzyme associated kinase, CARD-containing IL-1 beta ICE-kinase, RIP2
Molecular Weight 61194 DA
Gene ID 8767
NCBI Accession NP_003812
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 458-488) (ABIN392274) Western blot analysis of anti-RIPK2 Pab (ABIN392274) in Ramos cell line lysates (35 µ...
Western Blotting (WB) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 458-488) (ABIN392274) Western blot analysis of anti-RIPK2 Pab (ABIN392274) in mouse cerebellum tissue lysat...
Immunohistochemistry (IHC) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 458-488) (ABIN392274) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Chen, Clark: "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK." in: Biochemistry, Vol. 42, Issue 20, pp. 6310-20, 2003 (PubMed).

Munz, Hildt, Springer, Blau: "RIP2, a checkpoint in myogenic differentiation." in: Molecular and cellular biology, Vol. 22, Issue 16, pp. 5879-86, 2002 (PubMed).

Chin, Dempsey, Bruhn, Miller, Xu, Cheng: "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses." in: Nature, Vol. 416, Issue 6877, pp. 190-4, 2002 (PubMed).