Glutathione Peroxidase 1 antibody

Catalog No. ABIN400775

Product Details anti-Glutathione Peroxidase 1 Antibody

Target: Glutathione Peroxidase 1 (GPX1)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glutathione Peroxidase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: Recognizes Glutathione Peroxidase (GPX1).

Cross-Reactivity (Details): Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.

Characteristics: Synonyms: GSHPx-1, Cellular glutathione peroxidase

Purification: Purified

Immunogen: Recombinant Mouse protein purified from E. coli (Gpx1).

Clone: 13B2AF

Isotype: IgG1

Application Details

Application Notes: ELISA. Western Blot: 1/5000. Immunoprecipitation. Immunohistochemistry on Paraffin Sections: 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: HEPES containing 0.15 M Sodium Chloride, 0.01 % BSA as stabilizer, 0.03 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Glutathione Peroxidase 1

Target: Glutathione Peroxidase 1 (GPX1)

Alternative Name: Glutathione Peroxidase 1 / GPX1 (GPX1 Products)

Synonyms: Gpx antibody, ATGPX1 antibody, F13D4.40 antibody, F13D4_40 antibody, GLUTATHIONE PEROXIDASE 1 antibody, glutathione peroxidase 1 antibody, gshpx1 antibody, AI195024 antibody, AL033363 antibody, CGPx antibody, GPx-1 antibody, GSHPx-1 antibody, GPX1 antibody, gpx1 antibody, cb690 antibody, zgc:92737 antibody, zgc:103683 antibody, GPXD antibody, GSHPX1 antibody, GSHPx antibody, wu:fd42f12 antibody, wu:fj22d06 antibody, zgc:101700 antibody, glutathione peroxidase Gpx1 antibody, glutathione peroxidase antibody, glutathione peroxidase 1 antibody, glutathione peroxidase 1a antibody, glutathione peroxidase family protein antibody, proliferating cell nuclear antigen antibody, glutathione peroxidase 1b antibody, glutathione peroxidase 1 S homeolog antibody, gpx1 antibody, GPX1 antibody, gpx antibody, Gpx antibody, Gpx1 antibody, gpx1a antibody, POPTR_0003s12620g antibody, Pcna antibody, LBL_RS00590 antibody, btuE-1 antibody, GPX2 antibody, gpx1b antibody, gpx1.S antibody

Background: Glutathione peroxidases(GPxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. This protein is one of the most important antioxidant enzymes in humans. This protein has been reported to protect cultured breast cancer cells from CD95-induced apoptosis and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. There are several isoforms which differ in their primary structure and localization. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis specific secretory GPx(eGPxor GPx5)isoforms, possess selenocysteine at the active site. One allele of the Glutathione Peroxidase 1 gene is significantly associated with an increased breast cancer risk.Synonyms: Cellular glutathione peroxidase, GSHPx-1

Gene ID: 2876

UniProt: P07203

Pathways: Thyroid Hormone Synthesis, Sensory Perception of Sound, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome