anti-PPP2R1A antibody (Protein Phosphatase 2, Regulatory Subunit A, alpha) (N-Term)

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Antigen
Synonyms pp2a-aalpha, pp2aaalpha, pr65a, c-sis, pdgf2, ppp2r1a, sis, ssv, 6330556D22Rik, PP2A, PR65, wu:fa02h04, zgc:56296, PP2A-Aalpha, PP2AAALPHA, PR65A
Alternatives
Epitope
N-Term
(30), (17), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(84), (33), (32), (8), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(64), (12), (9), (2)
Clonality
Polyclonal
Conjugate
This PPP2R1A antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(71), (34), (14), (12), (11), (5), (3), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human PPP2R1A
Blocking Peptide Blocking peptide for this product available: PPP2R1A (Protein Phosphatase 2 (Formerly 2A) , alpha Isoform) (Regulatory Subunit A) peptide (ABIN982118)
Sequence KAVESLRAIS HEHSPSDLEA HFVPLVKRLA GGDWFTSRTS ACGLFSVCYP
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against PPP2R1A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PPP2R1A (PPP2R1A Antibody Abstract)
Background PPP2R1A is a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. PPP2R1A is an alpha isoform of the constant regulatory subunit A.This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
Molecular Weight 65 kDa
Gene ID 5518
NCBI Accession NP_055040, NM_014225
UniProt P30153
Research Area Signaling, Kinases/Phosphatases
Pathways PI3K-Akt Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 589 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-PPP2R1A antibody (Protein Phosphatase 2, Regulatory Subunit A, alpha) (N-Term) (ABIN406619) WB Suggested Anti-PPP2R1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Background publications Hong, Wang, Gao et al.: "Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 12119-26, 2007 (PubMed).

Catalog No. ABIN406619
$289.00
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