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Details for Product No. ABIN453175

TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser423) antibody

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Antigen
Synonyms MAP3K7IP1, 3'-Tab1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Epitope
»Alternatives Ser423
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN453175
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide selected from the amino acid residues surrounding S423 of human MAP3K7IP1
Specificity This antibody reacts to MAP3K7IP1.
Purification Affinity chromatography on Protein A
Alternative Name TAB1 / MAP3K7IP1
Background MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
Alternate names: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1
Gene ID 10454
NCBI Accession NP_006107
UniProt Q15750
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Arch, Gedrich, Thompson: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, 1998 (PubMed).

Yamaguchi, Nagai, Ninomiya-Tsuji et al.: "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway." in: The EMBO journal, Vol. 18, Issue 1, pp. 179-87, 1999 (PubMed).

Alternatives for antigen "TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1)", type "Antibodies"
Hosts (80), (12), (1)
Reactivities (91), (55), (48), (38), (38), (37), (13), (1), (1)
Applications (59), (30), (30), (14), (12), (9), (6), (5), (2), (2), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (16), (12), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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