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NOTCH2 antibody (Middle Region)

NOTCH2 Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN486974
  • Target See all NOTCH2 Antibodies
    NOTCH2 (Notch 2 (NOTCH2))
    Binding Specificity
    • 16
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 62
    • 55
    • 31
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig
    Host
    • 73
    • 5
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 70
    • 10
    • 2
    Polyclonal
    Conjugate
    • 44
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This NOTCH2 antibody is un-conjugated
    Application
    • 48
    • 32
    • 26
    • 26
    • 17
    • 16
    • 14
    • 12
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    FPASVGKYPT PPSQHSYASS NAAERTPSHS GHLQGEHPYL TPSPESPDQW
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against NOTCH2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NOTCH2
    Top Product
    Discover our top product NOTCH2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 2471 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tilley, Harvey, Heguy, Hackett, Wang, OConnor, Crystal: "Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 6, pp. 457-66, (2009) (PubMed).

  • Target
    NOTCH2 (Notch 2 (NOTCH2))
    Alternative Name
    NOTCH2 (NOTCH2 Products)
    Synonyms
    AGS2 antibody, HJCYS antibody, hN2 antibody, AI853703 antibody, N2 antibody, notch6 antibody, sb:cb884 antibody, neurogenic locus notch homolog protein 2 antibody, notch 2 antibody, notch 3 antibody, LOC581186 antibody, NOTCH2 antibody, notch3 antibody, Notch2 antibody, notch2 antibody
    Background
    NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AGS2, hN2, HJCYS
    Protein Interaction Partner: ASB14, EGFL7, LATS2, ANKRD28, UBC, SMAD1, NOTCH1, SIN3A, SPEN, SEC24C, TJP1, PSMB1, PLAUR, PCMT1, NDUFV2, NDUFV1, MYOC, CRKL, MAML3, MAML2, CNTN1, DLL1, MAML1, GSK3B, DTX1, MFNG, LFNG, JAG2, JAG1, PSEN2, RBPJ, PSEN1, tat,
    Protein Size: 2471
    Molecular Weight
    85 kDa
    Gene ID
    4853
    NCBI Accession
    NM_024408, NP_077719
    UniProt
    Q04721
    Pathways
    Notch Signaling, Stem Cell Maintenance
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