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CASP5 antibody (Intermediate Domain)

CASP5 Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499567
  • Target See all CASP5 Antibodies
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reactivity
    • 43
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 40
    • 3
    Rabbit
    Clonality
    • 33
    • 10
    Polyclonal
    Conjugate
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This CASP5 antibody is un-conjugated
    Application
    • 25
    • 15
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    Caspase-5 antibody was raised against a 14 amino acid peptide from the center of human Caspase-5.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human Casp-5 / (ICH-3 / ICE rel III (Intermediate Domain) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product CASP5 Primary Antibody
  • Application Notes
    ELISA. Western Blot: Casp-5 antibody can be used for the detection of caspase-5 at 0.5 - 1 μg/mLDepending on cell lines or tissues used, other cleavage products may be observed. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Alternative Name
    Caspase-5 (CASP5 Products)
    Synonyms
    ICE(rel)III antibody, ICEREL-III antibody, ICH-3 antibody, CASP5 antibody, caspase 5 antibody, caspase-5 antibody, CASP5 antibody, LOC100437308 antibody
    Background
    Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma (5).Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease
    Gene ID
    838
    UniProt
    P51878
    Pathways
    Inflammasome
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