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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody

Details for Product No. ABIN500837
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Antigen
Synonyms
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI78975 ... show more
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI789753, AU040360, DAP-1, Gkap, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3C, SMT3H3, UBL1, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1, ATSUMO1, F10M23.180, F10M23_180, SMALL UBIQUITIN-LIKE MODIFIER 1, SUM1, SUMO 1, small ubiquitin-like modifier 1, pigSUMO1, SENTRIN, SMTP3, SUMO-1, Smt3C, Ubl1, hm:zeh0670, wu:fb74c02, wu:fd12c02, zgc:65934, zgc:85634 show less
Epitope
N-Term
(23), (11), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(141), (68), (63), (23), (23), (12), (11), (2), (1), (1), (1), (1)
Host
Rabbit
(123), (22), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(117), (54), (44), (34), (29), (29), (27), (20), (4), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Request Want additional data for this product?

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Catalog No. ABIN500837
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Immunogen Sumo antibody was raised against a 14 amino acid peptide from near the amino terminus of human sumo.
Isotype IgG
Specificity This antibody detects SUMO1. It will only recognize isoform 1.
Purification Peptide affinity chromatography
Alternative Name SUMO1
Background The sumo family of proteins is related both structurally and functionally to ubiquitin in that they are post-translationally attached to the e-amino group of a lysine residue of the substrate protein. This sumoylation plays a number of roles in DNA replication and repair, protein targeting to various subnuclear structures, and the regulation of numerous cellular processes including the inflammatory response in mammalian cells. Sumo was initially identified as a covalent modification of RanGAP1 in studies on nuclear import in mammalian cells. More recently, sumo has been shown to be involved in the regulation of transcription factors, possibly by enhancing their interactions with co-repressors. Sumo is also thought to play some role in the modulation of ubiquitin-mediated degradation of proteins by acting as an inhibitor. At least four different isoforms of sumo are known to exist.
Alternate names: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin- related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1
Gene ID 7341
NCBI Accession AAH66306
Research Area Signaling, Proteases, DNA/RNA
Application Notes ELISA. Immunohistochemistry on paraffin sections. Western blot: 0.5 – 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Matunis, Coutavas, Blobel: "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex." in: The Journal of cell biology, Vol. 135, Issue 6 Pt 1, pp. 1457-70, 1997 (PubMed).

Desterro, Rodriguez, Hay: "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation." in: Molecular cell, Vol. 2, Issue 2, pp. 233-9, 1998 (PubMed).

Dohmen: "SUMO protein modification." in: Biochimica et biophysica acta, Vol. 1695, Issue 1-3, pp. 113-31, 2004 (PubMed).

Validation Images
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