Signal Transducer and Activator of Transcription 5A (STAT5A) (C-Term) antibody

Details for Product No. ABIN501656
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Antigen
Synonyms STAT5A, STAT5, MGF, AA959963, Stat5, STAT5A/MGF, STATA5
Epitope
C-Term
(63), (40), (24), (20), (17), (10), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Pig (Porcine), Cow (Bovine), Human
(305), (174), (152), (50), (48), (38), (24), (2), (1)
Host
Rabbit
(276), (50), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1)
Application
Western Blotting (WB)
(268), (140), (105), (80), (40), (35), (29), (25), (25), (14), (9), (9), (8), (4), (2), (2), (2)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN501656
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human STAT5A
Sequence DQAPSPAVCP QAPYNMYPQN PDHVLDQDGE FDLDETMDVA RHVEELLRRP
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Horse : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against STAT5A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name STAT5A
Background STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
Molecular Weight 91 kDa
Gene ID 6776
NCBI Accession NM_003152, NP_003143
UniProt P42229
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 794 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Product cited in: Murayama, Ohmori, Fujimura et al.: "Epigenetic control of rDNA loci in response to intracellular energy status." in: Cell, Vol. 133, Issue 4, pp. 627-39, 2008 (PubMed).

Background publications Subtil-Rodríguez, Millán-Ariño, Quiles et al.: "Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking." in: Molecular and cellular biology, Vol. 28, Issue 11, pp. 3830-49, 2008 (PubMed).

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