STAT5A antibody (AA 583-794)

Catalog No. ABIN1098129

Cited in 2+ publications. The Mouse Monoclonal anti-STAT5A antibody (Clone 6D4) (ABIN1098129) specifically detects STAT5A in WB, IHC, ELISA, FACS and ICC. The antibody is reactive with Human samples.

Quick Overview for STAT5A antibody (AA 583-794) (ABIN1098129)

Target: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT5A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 6D4

Product Details anti-STAT5A Antibody

Binding Specificity: AA 583-794

Purpose: STAT5A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human STAT5A (AA: 583-794 ) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-STAT5A antibody (ABIN1098129)

Cerliani, Guillardoy, Giulianelli, Vaque, Gutkind, Vanzulli, Martins, Zeitlin, Lamb, Lanari: "Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer." in: Cancer research, Vol. 71, Issue 10, pp. 3720-31, (2011) (PubMed).

Warsch, Kollmann, Eckelhart, Fajmann, Cerny-Reiterer, Hölbl, Gleixner, Dworzak, Mayerhofer, Hoermann, Herrmann, Sillaber, Egger, Valent, Moriggl, Sexl: "High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia." in: Blood, Vol. 117, Issue 12, pp. 3409-20, (2011) (PubMed).

Target Details for STAT5A

Target: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Alternative Name: STAT5A

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Molecular Weight: 90.6 kDa

Gene ID: 6776

UniProt: P42229

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation