Connexin 43/GJA1 antibody (C-Term)
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- Target See all Connexin 43/GJA1 (GJA1) Antibodies
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse, Dog, Chicken, Zebrafish (Danio rerio), Sheep, Finch, Non-Human Primate, Xenopus laevis
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Connexin 43/GJA1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- Specific for the ~43k Connexin-43 protein.
- Cross-Reactivity (Details)
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Species reactivity (expected):Human, Chicken, Canine (Dog), Finch, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat. - Purification
- Affinity Chromatography.
- Immunogen
- Peptide corresponding to amino acid residues from the C-terminal region of rat Connexin-43.
- Isotype
- IgG
- Top Product
- Discover our top product GJA1 Primary Antibody
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- Application Notes
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Target
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
- Alternative Name
- GJA1 / Cx43 (GJA1 Products)
- Synonyms
- AVSD3 antibody, CX43 antibody, DFNB38 antibody, GJAL antibody, HLHS1 antibody, HSS antibody, ODDD antibody, Cx43 antibody, AU042049 antibody, AW546267 antibody, Cnx43 antibody, Cx43alpha1 antibody, Gja-1 antibody, Npm1 antibody, connexin43 antibody, cx43a1 antibody, gja1 antibody, zfCx43.3 antibody, connexin 43 antibody, gja1-A antibody, cx43 antibody, gjal antibody, oddd antibody, dfnb38 antibody, gap junction protein alpha 1 antibody, gap junction protein, alpha 1 antibody, connexin 43 antibody, gap junction protein alpha 1 L homeolog antibody, CONNEXIN 43 protein antibody, GJA1 antibody, Gja1 antibody, cx43 antibody, gja1.L antibody, gja1 antibody, CONNEXIN 43 antibody
- Background
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
- Gene ID
- 2697
- NCBI Accession
- NP_000156
- UniProt
- P17302
- Pathways
- MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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