This antibody will detect Isoform 1 (152 kDa), Isoform 3 (72 kDa), Isoform 5 (69 kDa) and Isoform 6 (53 kDa) because the immunogenic sequence is missing in Isoform 2, 4 and 7.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse, Rat, ChickenSpecies reactivity (tested):Human
Purification
Purified using peptide immunoaffinity column
Immunogen
The immunogen for anti-WHSC1 antibody: synthetic peptide directed towards the N terminal of human WHSC1
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Reconstitution
Add 50 μL of distilled water to a final concentration of 1 mg/mL.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.Synonyms: KIAA1090, MMSET, Multiple myeloma SET domain-containing protein, NSD2, Nuclear SET domain-containing protein 2, Probable histone-lysine N-methyltransferase NSD2, TRX5, Trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein