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HMGB1 antibody (AA 1-215)

HMGB1 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 1D5 unconjugated
Catalog No. ABIN561281
  • Target See all HMGB1 Antibodies
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Binding Specificity
    • 20
    • 16
    • 16
    • 11
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-215
    Reactivity
    • 156
    • 88
    • 87
    • 14
    • 12
    • 12
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 137
    • 29
    • 2
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 127
    • 45
    Monoclonal
    Conjugate
    • 89
    • 17
    • 17
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This HMGB1 antibody is un-conjugated
    Application
    • 145
    • 63
    • 47
    • 46
    • 32
    • 30
    • 27
    • 26
    • 21
    • 10
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Mouse monoclonal antibody raised against a full length recombinant HMGB1.
    Sequence
    MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE
    Cross-Reactivity
    Human
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    HMGB1 (AAH03378.1, 1 a.a. ~ 215 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    1D5
    Isotype
    IgG2a
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Ko, Hsu, Hsieh, Lien, Lee, Kou: "High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers." in: Respirology (Carlton, Vic.), Vol. 19, Issue 2, pp. 253-61, (2014) (PubMed).

    Demoulin, Herfs, Somja, Roncarati, Delvenne, Hubert: "HMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells." in: International journal of cancer. Journal international du cancer, (2014) (PubMed).

    Hirano, Yoshioka, Yunoue, Fujio, Yonezawa, Niiro, Habu, Oyoshi, Sugata, Kamezawa, Arimura, Hanaya, Tokimura, Tokudome, Arita: "TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 6, pp. 628-37, (2012) (PubMed).

    Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: "Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3390-5, (2009) (PubMed).

    Kijanka, Hector, Kay, Murray, Cummins, Murphy, MacCraith, Prehn, Kenny: "Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer." in: Gut, Vol. 59, Issue 1, pp. 69-78, (2009) (PubMed).

  • Target
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Alternative Name
    HMGB1 (HMGB1 Products)
    Synonyms
    HMG1 antibody, HMG3 antibody, SBP-1 antibody, DEF antibody, HMG-1 antibody, Hmg1 antibody, amphoterin antibody, p30 antibody, hmgb1 antibody, ik:tdsubc_1a5 antibody, wu:fb23c02 antibody, xx:tdsubc_1a5 antibody, zgc:56110 antibody, zgc:77104 antibody, hmg-1 antibody, hmg3 antibody, sbp-1 antibody, hmg1 antibody, HMGB1 antibody, Ac2-008 antibody, high mobility group box 1 antibody, high-mobility group box 1 antibody, high mobility group box 1a antibody, high mobility group box 1 L homeolog antibody, high mobility group protein B1 antibody, HMGB1 antibody, Hmgb1 antibody, hmgb1 antibody, hmgb1a antibody, hmgb1.L antibody, LOC100359149 antibody
    Background
    Full Gene Name: high-mobility group box 1
    Synonyms: DKFZp686A04236,HMG1,HMG3,SBP-1
    Gene ID
    3146
    Pathways
    p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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