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TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody

Details for Product No. ABIN565080, Supplier: Log in to see
Antigen
  • TARDBP
  • TDP43
  • DKFZp459I2127
  • tardbp
  • ALS10
  • TDP-43
  • 1190002A23Rik
  • C85084
  • Tdp43
  • wu:fb77f02
  • wu:fc52g10
Epitope
AA 1-260, full length
27
17
16
13
12
11
8
7
7
3
3
3
3
2
2
1
1
Reactivity
Human
153
72
55
11
8
8
8
7
6
4
3
2
1
Host
Mouse
112
32
15
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), RNA Interference (RNAi), ELISA, Western Blotting (WB)
140
70
51
38
27
16
11
9
5
5
4
2
2
Supplier
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Immunogen TARDBP (AAH01487.1, 1 a.a. ~ 260 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA
Clone 2E2-D3
Isotype IgG1 kappa
Cross-Reactivity Human
Alternative Name TARDBP (TARDBP Antibody Abstract)
Background Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43
Gene ID 23435
NCBI Accession NP_031401, NM_007375
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Immunostaining (ISt) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoperoxidase of monoclonal antibody to TARDBP on formalin-fixed paraffin-embedded...
Immunofluorescence (IF) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell. [antibody concentra...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) TARDBP monoclonal antibody (M01), clone 2E2-D3 Western Blot analysis of TARDBP expres...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARD...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP mo...
Immunoprecipitation (IP) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoprecipitation of TARDBP transfected lysate using anti-TARDBP monoclonal antibod...
ELISA image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Detection limit for recombinant GST tagged TARDBP is 0.3 ng/ml as a capture antibody.
 image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot detection against Immunogen (54.34 KDa) .
Product cited in: Rosenbohm, Buckert, Gerischer et al.: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, 2015 (PubMed).

Saldi, Ash, Wilson et al.: "TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA." in: The EMBO journal, Vol. 33, Issue 24, pp. 2947-66, 2014 (PubMed).

Alafuzoff, Pikkarainen, Neumann et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), 2014 (PubMed).

Kara, Kiely, Proukakis et al.: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, 2014 (PubMed).

Robinson, Thompson, Weedon et al.: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, 2014 (PubMed).

Wenqiang, Lonskaya, Hebron et al.: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, 2014 (PubMed).

Hans, Fiesel, Strong et al.: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, 2014 (PubMed).

Ohta, Tremblay, Schneider et al.: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, 2014 (PubMed).

Carlomagno, Zhang, Davis et al.: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, 2014 (PubMed).

Araki, Minegishi, Motoki et al.: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, 2014 (PubMed).

Cortese, Plagnol, Brady et al.: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, 2014 (PubMed).

De Marco, Lomartire, Mandili et al.: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, 2014 (PubMed).

Gelpi, Navarro-Otano, Tolosa et al.: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, 2014 (PubMed).

Yan, Wang, Wei et al.: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, 2014 (PubMed).

Balasa, Gelpi, Rey et al.: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, 2014 (PubMed).

Walker, Soo, Sundaramoorthy et al.: "ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81170, 2013 (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó et al.: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, 2014 (PubMed).

Hebron, Chen, Miessau et al.: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, 2014 (PubMed).

Iovino, Pfisterer, Holton et al.: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, 2014 (PubMed).

Lashley, Rohrer, Mahoney et al.: "A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia." in: Neuropathology and applied neurobiology, Vol. 40, Issue 4, pp. 502-13, 2014 (PubMed).

Maruyama, Morino, Ito et al.: "Mutations of optineurin in amyotrophic lateral sclerosis. ..." in: Nature, Vol. 465, Issue 7295, pp. 223-6, 2010 (PubMed).