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TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody

Details for Product No. ABIN565080, Supplier: Log in to see
Antigen
  • 1190002A23Rik
  • ALS10
  • C85084
  • DKFZp459I2127
  • TARDBP
  • tardbp
  • TDP-43
  • TDP43
  • Tdp43
  • wu:fb77f02
  • wu:fc52g10
Epitope
AA 1-260, full length
29
28
19
19
16
14
12
12
8
7
6
5
3
3
2
2
1
1
1
Reactivity
Human
232
110
80
28
23
23
20
19
12
8
6
4
2
1
Host
Mouse
130
92
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
10
8
6
5
5
5
5
5
4
4
4
3
3
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), RNA Interference (RNAi), ELISA, Western Blotting (WB)
218
112
69
63
48
48
20
12
10
5
5
4
3
2
Supplier
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Immunogen TARDBP (AAH01487.1, 1 a.a. ~ 260 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA
Clone 2E2-D3
Isotype IgG1 kappa
Cross-Reactivity Human
Alternative Name TARDBP (TARDBP Antibody Abstract)
Background Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43
Gene ID 23435
NCBI Accession NP_031401, NM_007375
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Immunostaining (ISt) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoperoxidase of monoclonal antibody to TARDBP on formalin-fixed paraffin-embedded...
Immunofluorescence (IF) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell. [antibody concentra...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) TARDBP monoclonal antibody (M01), clone 2E2-D3 Western Blot analysis of TARDBP expres...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARD...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP mo...
Immunoprecipitation (IP) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoprecipitation of TARDBP transfected lysate using anti-TARDBP monoclonal antibod...
ELISA image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Detection limit for recombinant GST tagged TARDBP is 0.3 ng/ml as a capture antibody.
 image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot detection against Immunogen (54.34 KDa) .
Product cited in: Rosenbohm, Buckert, Gerischer, Walcher, Kassubek, Rottbauer, Ludolph, Bernhardt: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, 2015 (PubMed).

Iovino, Pfisterer, Holton, Lashley, Swingler, Calo, Treacy, Revesz, Parmar, Goedert, Muqit, Spillantini: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, 2014 (PubMed).

Hebron, Chen, Miessau, Lonskaya, Moussa: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, 2014 (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó, Sánchez-Valle, Hernández, Amer, Antón-Aguirre, Alcolea, Fortea, Ferrer, van der Zee, Dillen, Van Broeckhoven, Molinuevo, Blesa, Clarimón, Lleó: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, 2014 (PubMed).

Yan, Wang, Wei, Gaertig, Lai, Li, Li: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, 2014 (PubMed).

De Marco, Lomartire, Mandili, Lupino, Buccinnà, Ramondetti, Moglia, Novelli, Piccinini, Mostert, Rinaudo, Chiò, Calvo: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, 2014 (PubMed).

Cortese, Plagnol, Brady, Simone, Lashley, Acevedo-Arozena, de Silva, Greensmith, Holton, Hanna, Fisher, Fratta: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, 2014 (PubMed).

Ohta, Tremblay, Schneider, Bennett, Calon, Julien: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, 2014 (PubMed).

Gelpi, Navarro-Otano, Tolosa, Gaig, Compta, Rey, Martí, Hernández, Valldeoriola, Reñé, Ribalta: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, 2014 (PubMed).

Carlomagno, Zhang, Davis, Lin, Cook, Dunmore, Tay, Menkosky, Cao, Petrucelli, Deture: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, 2014 (PubMed).

Kara, Kiely, Proukakis, Giffin, Love, Hehir, Rantell, Pandraud, Hernandez, Nacheva, Pittman, Nalls, Singleton, Revesz, Bhatia, Quinn, Hardy, Holton, Houlden: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, 2014 (PubMed).

Balasa, Gelpi, Rey, Vila, Ramió-Torrentà, Quiles Granado, Molina Latorre, Lepidi, Raoult, Saiz: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, 2014 (PubMed).

Araki, Minegishi, Motoki, Kume, Hohjoh, Araki, Tamaoka: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, 2014 (PubMed).

Hans, Fiesel, Strong, Jäckel, Rasse, Geisler, Springer, Schulz, Voigt, Kahle: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, 2014 (PubMed).

Robinson, Thompson, Weedon, Rollinson, Pickering-Brown, Snowden, Davidson, Mann: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, 2014 (PubMed).

Alafuzoff, Pikkarainen, Neumann, Arzberger, Al-Sarraj, Bodi, Bogdanovic, Bugiani, Ferrer, Gelpi, Gentleman, Giaccone, Graeber, Hortobagyi, Ince, Ironside, Kavantzas, King, Korkolopoulou, Kovács et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), 2014 (PubMed).

Wenqiang, Lonskaya, Hebron, Ibrahim, Olszewski, Neale, Moussa: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, 2014 (PubMed).

Lashley, Rohrer, Mahoney, Gordon, Beck, Mead, Warren, Rossor, Revesz: "A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia." in: Neuropathology and applied neurobiology, Vol. 40, Issue 4, pp. 502-13, 2014 (PubMed).

Saldi, Ash, Wilson, Gonzales, Garrido-Lecca, Roberts, Dostal, Gendron, Stein, Blumenthal, Petrucelli, Link: "TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA." in: The EMBO journal, Vol. 33, Issue 24, pp. 2947-66, 2014 (PubMed).

Gelpi, Soler Insa, Parchi, Saverioni, Yagüe, Nos, Martínez-Saez, Ribalta, Ferrer, Sanchez-Valle: "Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 33, Issue 2, pp. 204-8, 2013 (PubMed).