TAR DNA Binding Protein (TARDBP) (full length) antibody

Details for Product No. ABIN565080
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Antigen
Synonyms TARDBP, TDP43, DKFZp459I2127, tardbp, ALS10, TDP-43, 1190002A23Rik, C85084, Tdp43, wu:fb77f02, wu:fc52g10
Epitope
full length
(29), (25), (14), (14), (13), (11), (7), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(162), (64), (53), (11), (8), (7), (7), (6), (5), (3), (2), (1), (1)
Host
Mouse
(113), (35), (16), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP), RNA Interference (RNAi)
(147), (65), (53), (34), (26), (19), (10), (10), (5), (4), (4), (3), (2), (1), (1), (1)
Pubmed 32 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 11 to 12 Business Days
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Immunogen TARDBP (AAH01487.1, 1 a.a. ~ 260 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 kDa.
Immunogen sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA
Clone 2E2-D3
Isotype IgG1 kappa
Alternative Name TARDBP (TARDBP Antibody Abstract)
Background Gene: TAR DNA binding protein
Synonyms: ALS10, TDP-43
Gene ID 23435
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20
Storage Comment Store at -20
Supplier Images
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody Immunoperoxidase of monoclonal antibody to TARDBP on formalin-fixed paraffin-embedded...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (2) Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell. (antibody concentra...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (3) TARDBP monoclonal antibody (M01), clone 2E2-D3 Western Blot analysis of TARDBP expres...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (4) Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARD...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (5) Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP mo...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (6) Immunoprecipitation of TARDBP transfected lysate using anti-TARDBP monoclonal antibod...
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (7) Detection limit for recombinant GST tagged TARDBP is 0.3 ng/mL as a capture antibody.
anti-TAR DNA Binding Protein (TARDBP) (full length) antibody (8) Western Blot detection against Immunogen (54.34 KDa) .
Product cited in: Alafuzoff, Pikkarainen, Neumann et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), 2014 (PubMed).

Robinson, Thompson, Weedon et al.: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, 2014 (PubMed).

Hans, Fiesel, Strong et al.: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, 2014 (PubMed).

Araki, Minegishi, Motoki et al.: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, 2014 (PubMed).

Cortese, Plagnol, Brady et al.: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, 2014 (PubMed).

De Marco, Lomartire, Mandili et al.: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, 2014 (PubMed).

Balasa, Gelpi, Rey et al.: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, 2014 (PubMed).

Walker, Soo, Sundaramoorthy et al.: "ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81170, 2013 (PubMed).

Iovino, Pfisterer, Holton et al.: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, 2014 (PubMed).

Grau-Rivera, Gelpi, Rey et al.: "Prominent psychiatric symptoms in patients with Parkinson's disease and concomitant argyrophilic grain disease." in: Journal of neurology, Vol. 260, Issue 12, pp. 3002-9, 2013 (PubMed).

Finsterer, Stöllberger, Kovacs: "Asymptomatic hyper-creatine-kinase-emia as sole manifestation of inclusion body myositis." in: Neurology international, Vol. 5, Issue 2, pp. 34-6, 2013 (PubMed).

Mundiñano, Hernandez, Dicaudo et al.: "Reduced cholinergic olfactory centrifugal inputs in patients with neurodegenerative disorders and MPTP-treated monkeys." in: Acta neuropathologica, Vol. 126, Issue 3, pp. 411-25, 2013 (PubMed).

Tong, Huang, Bi et al.: "Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats." in: The EMBO journal, Vol. 32, Issue 13, pp. 1917-26, 2013 (PubMed).

Gelpi, Cullel, Navarro-Otano et al.: "Globular glial-like inclusions in a patient with advanced Alzheimer's disease." in: Acta neuropathologica, Vol. 126, Issue 1, pp. 155-7, 2013 (PubMed).

Dayton, Gitcho, Orchard et al.: "Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 21, Issue 7, pp. 1324-34, 2013 (PubMed).

Iyer, Prabowo, Anink et al.: "Cell injury and premature neurodegeneration in focal malformations of cortical development." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 1, pp. 1-17, 2013 (PubMed).

Bi, Huang, Tong et al.: "Reactive astrocytes secrete lcn2 to promote neuron death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 10, pp. 4069-74, 2013 (PubMed).

Doherty, Rohrer, Lees et al.: "Primary progressive aphasia with parkinsonism." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 28, Issue 6, pp. 741-6, 2013 (PubMed).

Hebron, Lonskaya, Sharpe et al.: "Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6)." in: The Journal of biological chemistry, Vol. 288, Issue 6, pp. 4103-15, 2013 (PubMed).

Watanabe, Kaneko, Yamanaka: "Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins." in: The Journal of biological chemistry, Vol. 288, Issue 5, pp. 3641-54, 2013 (PubMed).

López-González, Carmona, Blanco et al.: "Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains." in: Brain pathology (Zurich, Switzerland), Vol. 23, Issue 2, pp. 144-53, 2013 (PubMed).

Background publications Kara, Kiely, Proukakis et al.: "A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, 2014 (PubMed).

Ohta, Tremblay, Schneider et al.: "Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, 2014 (PubMed).

Carlomagno, Zhang, Davis et al.: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, 2014 (PubMed).

Gelpi, Navarro-Otano, Tolosa et al.: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, 2014 (PubMed).

Yan, Wang, Wei et al.: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, 2014 (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó et al.: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, 2014 (PubMed).

Hebron, Chen, Miessau et al.: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, 2014 (PubMed).

Nishimoto, Nakagawa, Hirose et al.: "The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis." in: Molecular brain, Vol. 6, pp. 31, 2013 (PubMed).

Iranzo, Tolosa, Gelpi et al.: "Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study." in: The Lancet. Neurology, Vol. 12, Issue 5, pp. 443-53, 2013 (PubMed).

Swarup, Audet, Phaneuf et al.: "Abnormal regenerative responses and impaired axonal outgrowth after nerve crush in TDP-43 transgenic mouse models of amyotrophic lateral sclerosis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 50, pp. 18186-95, 2012 (PubMed).

Tong, Huang, Bi et al.: "XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats." in: Journal of neurochemistry, Vol. 123, Issue 3, pp. 406-16, 2012 (PubMed).

Validation Images
Catalog No. ABIN565080
330.00 $
Plus shipping costs $45.00 and $22.00 dry ice
Quantity
Price
100 μg
330.00 $

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