NLRP3 antibody (C-Term)

Catalog No. ABIN569576

The Goat Polyclonal anti-NLRP3 antibody is suitable to detect NLRP3 in samples from Human, Rat and Cow. It has been validated for FACS and EIA.

Quick Overview for NLRP3 antibody (C-Term) (ABIN569576)

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reactivity: Human, Rat, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This NLRP3 antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Product Details anti-NLRP3 Antibody

Binding Specificity: C-Term

Sequence: C-EKPELTVVFE PSW

Specificity: Recognizes CIAS1/Cryopyrin (C-Term).

Cross-Reactivity (Details): Species reactivity (expected):Rat and Bovine.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: synthetic peptide corresponding to the C-Terminus of the protein sequence according to NP_001073289.1, NP_004886.3, NP_899632.1, NP_001120933.1, NP_001120934.1. Genename: NLRP3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NLRP3

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Alternative Name: NALP3

Background: Synonyms: C1orf7, CIAS1, LRR and PYD domains-containing protein 3, NACHT, NLRP3, PYPAF1

Gene ID: 114548

NCBI Accession: NP_001120934

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome