CTLA4 antibody (Cytotoxic T-Lymphocyte-Associated Protein 4)

Details for Product anti-CTLA4 Antibody No. ABIN610404, Supplier: Log in to see
Antigen
  • CTLA-4
  • CTLA4
  • CD152
  • Cd152
  • Ctla-4
  • Ly-56
  • CD
  • CELIAC3
  • GRD4
  • GSE
  • IDDM12
  • sCTLA4
  • cytotoxic T-lymphocyte-associated protein 4 precursor
  • cytotoxic T-lymphocyte-associated protein 4
  • CTLA-4
  • CTLA4
  • LOC100222727
  • Ctla4
Reactivity
Human
227
209
83
19
2
2
Host
Mouse
213
80
80
35
27
5
3
Clonality (Clone)
Monoclonal ()
Conjugate
This CTLA4 antibody is un-conjugated
54
35
35
14
10
8
8
7
7
7
6
6
5
5
5
5
5
3
3
3
3
2
2
2
2
2
1
Application
Functional Studies (Func), Flow Cytometry (FACS), ELISA
281
186
171
68
62
62
56
20
16
12
11
9
6
5
4
4
4
4
3
2
2
2
2
2
1
1
1
Options
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Immunogen Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein
Clone ANC152-2-8H5
Isotype IgG1, kappa
Fragment Fab fragment
Specificity CTLA-4 expressed on activated T cells.
Purification Gel filtration
Sterility 0.1 μm filtered
Alternative Name CTLA4 / CD152 (CTLA4 Antibody Abstract)
Background Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform
Gene ID 1493
UniProt P16410
Application Notes Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer 50 mM sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride. Product was 0.1 μm filtered, vialed under aseptic conditions. No preservative added
Preservative Without preservative
Handling Advice Do not freeze. Open under aseptic conditions.
Storage 4 °C
Storage Comment Store at +4°C. Do not freeze. Open under aseptic conditions.
Product cited in: Zundel, Swiersz, Giaccia: "Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1507-14, 2000 (PubMed).

Chitaev, Troyanovsky: "Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation." in: The Journal of cell biology, Vol. 142, Issue 3, pp. 837-46, 1998 (PubMed).

Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: "Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ..." in: The Journal of cell biology, Vol. 120, Issue 3, pp. 757-66, 1993 (PubMed).

Background publications Takeichi: "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis." in: Development (Cambridge, England), Vol. 102, Issue 4, pp. 639-55, 1988 (PubMed).