IL1R1 antibody (Extracellular Domain)

Catalog No. ABIN614470

This Mouse Monoclonal antibody specifically detects IL1R1 in IHC (p), RIA, IF and EIA. It exhibits reactivity toward Human.

Quick Overview for IL1R1 antibody (Extracellular Domain) (ABIN614470)

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1R1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Radioimmunoassay (RIA), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: 40101

Product Details anti-IL1R1 Antibody

Binding Specificity: Extracellular Domain

Specificity: These antibodies react with cell surface and soluble human IL-1 receptor. Specific epitopes are unknown, but they do partially inhibit (30-50 %) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for Human IL-2 or IL-4.

Purification: Affinity chromatography on Protein G

Immunogen: Extracellular domain of the type I Human IL-1 receptor.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS, pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL1R1

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Alternative Name: CD121a / IL1R1

Background: IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.Synonyms: IL-1R-alpha, IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I

Gene ID: 3554

NCBI Accession: NP_000868

UniProt: P14778

Pathways: NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints