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CDC25B antibody (pSer149)
CDC25B
Reactivity: Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CDC25B Antibody
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Target
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CDC25B
(Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))
Binding Specificity
All epitopes for CDC25B antibodies
pSer149
Reactivity
All reactivities for CDC25B antibodies
Mouse, Rat
Host
All hosts for CDC25B antibodies
Rabbit
Clonality
All clonalities for CDC25B antibodies
Polyclonal
Conjugate
All conjugates for CDC25B antibodies
This CDC25B antibody is un-conjugated
Application
All applications for CDC25B antibodies
Western Blotting (WB)
Sequence
F-R-S(p)-L-P
Specificity
This antibody detects endogenous level of Cdc25B protein only when phosphorylated at serine 149.
Cross-Reactivity (Details)
Species reactivity (tested):Mouse, rat
Purification
Affinity-chromatography using epitope-specific peptide
Immunogen
Peptide sequence around phosphorylation site of Serine 149 derived from Mouse Cdc25B.
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store (in aliquots) at -20 °C.
Target Details for CDC25B
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Target
CDC25B
(Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))
Alternative Name
Cdc25B (CDC25B Products )
Synonyms
CDC25B antibody, AI604853 antibody, cell division cycle 25B antibody, cdc25b antibody, CDC25B antibody, Cdc25b antibody
Background
Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Gene ID
12531
NCBI Accession
NP_001104545
UniProt
Q9DBN8
Pathways
Cell Division Cycle , M Phase , Autophagy
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