PYCARD antibody

Catalog No. ABIN643907

Product Details anti-PYCARD Antibody

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYCARD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Rabbit Anti-Human TMS1 (C-term.)

Specificity: This product recognises human TMS1, also known as apoptosis-associated speck-like protein containing a CARD (ASC). It was first identified as a cytosolic soluble protein that forms insoluble aggregates and promotes caspase-mediated apoptosis. The proapoptotic activity is mediated predominantly though the activation of caspase 9. It may also be a component of the inflammasome, where it associates with caspase 1, CARD8 and NALP2 to activate proinflammatory caspases. TMS1 is widely expressed in human tissue.

Purification: Purified

Immunogen: A peptide corresponding to aa182-195 of human TMS1.

Isotype: IgG

Application Details

Application Notes: Immunohistology - Frozen, Western Blotting

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Storage: -20 °C

Storage Comment: -20°C

Target Details for PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Alternative Name: TMS1 (PYCARD Products)

Synonyms: ASC antibody, CARD5 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, 9130417A21Rik antibody, Asc antibody, TNS1 antibody, masc antibody, asc1 antibody, zAsc antibody, zgc:109874 antibody, PYD and CARD domain containing antibody, PYCARD antibody, Pycard antibody, pycard antibody

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome